Osthole Promotes Bone Fracture Healing through Activation of BMP Signaling in Chondrocytes
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چکیده
منابع مشابه
Osthole Promotes Bone Fracture Healing through Activation of BMP Signaling in Chondrocytes
Osthole is a bioactive coumarin derivative and has been reported to be able to enhance bone formation and improve fracture healing. However, the molecular mechanism of Osthole in bone fracture healing has not been fully defined. In this study we determined if Osthole enhances bone fracture healing through activation of BMP2 signaling in mice. We performed unilateral open transverse tibial fract...
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Osteoporosis is defined as reduced bone mineral density with a high risk of fragile fracture. Current available treatment regimens include antiresorptive drugs such as estrogen receptor analogues and bisphosphates and anabolic agents such as parathyroid hormone (PTH). However, neither option is completely satisfactory because of adverse effects. It is thus highly desirable to identify novel ana...
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Fan Jin1, Yin Jian2, Chen Jian1 and Fang Jiahu1* 1Department of Orthopaedics, The First Affiliated Hospital of Nanjing Medical University, Jiangsu-210029, PR China 2Department of Orthopaedics, The Affiliated Jiangning Hospital of Nanjing Medical University, Jiangsu-211100, PR China *Corresponding author: Fang Jiahu, PhD, Department of Orthopaedics, The First Affiliated Hospital of Nanjing Medic...
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Autophagy is a crucial mediating process for normal bone cell function and metabolism in physiology or pathology. Rapamycin has been demonstrated to induce the autophagy pathway by inhibiting the mammalian target of rapamycin (mTOR) pathway. However, the contribution of autophagy in orthopedic diseases is rarely reported. The aim of the present study was to evaluate the capacity of pharmacologi...
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PURPOSE Transferring the bone morphogenetic protein 2 (BMP-2) genes into the tissues or cells can improve the bone healing of the fracture has been widely accepted. We evaluated the efficiency of using gene gun to transfer the BMP-2 gene thereby affected the healing of a fractured bone. METHODS The vector coding for BMP-2 was constructed by a non-replicating encephalo-myocarditis virus (ECMV)...
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ژورنال
عنوان ژورنال: International Journal of Biological Sciences
سال: 2017
ISSN: 1449-2288
DOI: 10.7150/ijbs.19986